Daniel S. Medwed's research revolves around the topic of wrongful convictions. His book, Prosecution Complex: America's Race to Convict and its Impact on the Innocent (2012), explores how even well-meaning prosecutors may contribute to wrongful convictions because of cognitive biases and an overly-deferential regime of legal and ethical rules. In 2013, he received the Robert D. Klein University Lectureship, which is awarded to a member of the faculty across Northeastern University, Massachusetts, who has obtained distinction in his or her field of study. He is also a Legal Analyst for WGBH News, Boston's local NPR and PBS affiliate.