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Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that...
Editeur :
Springer
Parution :
2011-04-30
ePub
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The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets...
Editeur :
Academic Press
Parution :
2011-04-28
PDF, epub sans DRM
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Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular...
Editeur :
Academic Press
Parution :
2011-04-28
epub sans DRM
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Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly...
Editeur :
Academic Press
Parution :
2011-04-28
PDF, epub sans DRM
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By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion...
Editeur :
Wiley-VCH
Parution :
2011-04-08
Collection :
Methods & Principles in Medicinal Chemistry
PDF, ePub
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Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction...
Editeur :
Wiley-VCH
Parution :
2011-03-31
Collection :
Methods & Principles in Medicinal Chemistry
PDF, ePub
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This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately...
Editeur :
Wiley
Parution :
2011-03-29
ePub
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Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of...
Editeur :
Springer
Parution :
2011-03-23
Collection :
Current Cancer Research
ePub
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This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes...
Editeur :
Humana
Parution :
2011-03-03
Collection :
Current Cancer Research
ePub
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A must-have guide for any professional in the drug manufacturing industry The Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA code. Clinical Trials...
Editeur :
Wiley
Parution :
2011-03-01
PDF
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RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers...
Editeur :
Wiley
Parution :
2011-03-01
ePub
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The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an...
Editeur :
Wiley
Parution :
2011-02-25
PDF, ePub
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The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the...
Editeur :
Academic Press
Parution :
2011-02-22
PDF sans DRM
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Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery...
Editeur :
Wiley
Parution :
2011-02-11
PDF, ePub
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This book guides the reader through FDA regulation guidelines and outlines a comprehensive strategy for cost reduction in regulatory affairs and compliance.This book explains six strategies to cost-effectively comply with FDA regulations while maintaining product safety...
Editeur :
Wiley
Parution :
2011-02-11
PDF, ePub
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Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate...
Editeur :
Elsevier Science
Parution :
2011-02-09
epub sans DRM
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Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor...
Editeur :
Springer
Parution :
2011-01-25
ePub
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"Dr. Paris has written an honest, balanced presentation of the ways in which psychiatric drugs are evaluated and prescribed. He highlights the complexity of the task, the limits of what is known and the mixed picture that research often produces. His conclusions are...
Editeur :
Wiley
Parution :
2011-01-13
PDF, ePub
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This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of...
Editeur :
Wiley
Parution :
2010-12-28
ePub
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Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of...
Editeur :
Academic Press
Parution :
2010-12-16
epub sans DRM
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