Téléchargez le livre : Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules

Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules



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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2016-06-09



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Description

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
 
Pages
266 pages
Collection
Springer Theses
Parution
2016-06-09
Marque
Springer
EAN papier
9783319390246
EAN EPUB
9783319390253
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
26
Taille du fichier
4731 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
94,94 €

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