Téléchargez le livre : Mathematical Modelling of Chromosome Replication and Replicative Stress

Mathematical Modelling of Chromosome Replication and Replicative Stress



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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2014-07-11



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Description

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.
This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.
A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.
Pages
76 pages
Collection
Springer Theses
Parution
2014-07-11
Marque
Springer
EAN papier
9783319088600
EAN EPUB
9783319088617
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
7
Taille du fichier
1464 Ko
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Prix
94,94 €

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