Téléchargez le livre : Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers

Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers



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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2013-07-11



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Description
Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals.
Pages
180 pages
Collection
Springer Theses
Parution
2013-07-11
Marque
Springer
EAN papier
9783319007076
EAN EPUB
9783319007083
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
18
Taille du fichier
3881 Ko
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Prix
94,94 €

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