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This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. 
Pages
191 pages
Collection
Advances in Experimental Medicine and Biology
Parution
2018-10-12
Marque
Springer
EAN papier
9789811313691
EAN PDF
9789811313707

Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
19
Taille du fichier
4086 Ko
Prix
116,04 €
EAN EPUB
9789811313707

Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
19
Taille du fichier
11725 Ko
Prix
116,04 €