Téléchargez le livre : Sample Size Determination in Clinical Trials with Multiple Endpoints

Sample Size Determination in Clinical Trials with Multiple Endpoints

de

, , ,

Éditeur :

Springer


Collection :

SpringerBriefs in Statistics

Paru le : 2015-08-20

eBook Téléchargement , DRM LCP 🛈 DRM Adobe 🛈
Lecture en ligne (streaming)
73,84 €
Téléchargement immédiat
Dès validation de votre commande
Image Louise Reader présentation

Louise Reader

Lisez ce titre sur l'application Louise Reader.

badge apple Application Louise Reader
badge Android Application Louise Reader
Description

This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area.
The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also brie?y examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespeci?ed non-ordering of endpoints.
 
Pages
95 pages
Collection
SpringerBriefs in Statistics
Parution
2015-08-20
Marque
Springer
EAN papier
9783319220048
EAN PDF
9783319220055
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
9
Taille du fichier
3942 Ko
Prix
73,84 €
EAN EPUB
9783319220055
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
9
Taille du fichier
1853 Ko
Prix
73,84 €

Suggestions personnalisées