Téléchargez le livre : Interferon: The 50th Anniversary

Interferon: The 50th Anniversary

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2007-08-29

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Description
Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.
Pages
392 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2007-08-29
Marque
Springer
EAN papier
9783540713289
EAN PDF
9783540713296
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
39
Taille du fichier
9400 Ko
Prix
210,99 €

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