Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome



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Springer


Paru le : 2015-10-26



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Description

This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.
Pages
240 pages
Collection
n.c
Parution
2015-10-26
Marque
Springer
EAN papier
9784431552697
EAN PDF
9784431552703

Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
24
Taille du fichier
3574 Ko
Prix
94,94 €
EAN EPUB
9784431552703

Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
24
Taille du fichier
1464 Ko
Prix
94,94 €

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