The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. This centre of excellence under Professor Michael Grant supports Drs. Ray Boot-Handford and Adrian Shuttleworth as academic appointments and attracts external funding to support Professor Martin Humphries and senior research fellow Dr. Karl Kadler (Wellcome Trust) and senior research fellow Dr. Shirley Ayad (Arthritis and Rheumatism Council).The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. This centre of excellence under Professor Michael Grant supports Drs. Ray Boot-Handford and Adrian Shuttleworth as academic appointments and attracts external funding to support Professor Martin Humphries and senior research fellow Dr. Karl Kadler (Wellcome Trust) and senior research fellow Dr. Shirley Ayad (Arthritis and Rheumatism Council).The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. This centre of excellence under Professor Michael Grant supports Drs. Ray Boot-Handford and Adrian Shuttleworth as academic appointments and attracts external funding to support Professor Martin Humphries and senior research fellow Dr. Karl Kadler (Wellcome Trust) and senior research fellow Dr. Shirley Ayad (Arthritis and Rheumatism Council).The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. This centre of excellence under Professor Michael Grant supports Drs. Ray Boot-Handford and Adrian Shuttleworth as academic appointments and attracts external funding to support Professor Martin Humphries and senior research fellow Dr. Karl Kadler (Wellcome Trust) and senior research fellow Dr. Shirley Ayad (Arthritis and Rheumatism Council).The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. This centre of excellence under Professor Michael Grant supports Drs. Ray Boot-Handford and Adrian Shuttleworth as academic appointments and attracts external funding to support Professor Martin Humphries and senior research fellow Dr. Karl Kadler (Wellcome Trust) and senior research fellow Dr. Shirley Ayad (Arthritis and Rheumatism Council).