Téléchargez le livre : Biotransformation and Metabolite Elucidation of Xenobiotics

Biotransformation and Metabolite Elucidation of Xenobiotics

Characterization and Identification

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Éditeur :

Wiley


Paru le : 2011-03-23



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Description
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.
The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.
Pages
344 pages
Collection
n.c
Parution
2011-03-23
Marque
Wiley
EAN papier
9780470504789
EAN EPUB
9781118097779
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
344
Taille du fichier
7414 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
137,10 €

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