Téléchargez le livre : Preclinical Development Handbook

Preclinical Development Handbook

ADME and Biopharmaceutical Properties

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Éditeur :

Wiley-Interscience


Collection :

Pharmaceutical Development Series

Paru le : 2008-03-11



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Description
A clear, straightforward resource to guide you through preclinical drug development

Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.

Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Among the key topics covered are:
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Modeling and informatics in drug design
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Bioanalytical chemistry
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Absorption of drugs after oral administration
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Transporter interactions in the ADME pathway of drugs
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Metabolism kinetics
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Mechanisms and consequences of drug-drug interactions

Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.

This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Pages
1360 pages
Collection
Pharmaceutical Development Series
Parution
2008-03-11
Marque
Wiley-Interscience
EAN papier
9780470248478
EAN PDF
9780470249024
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
1360
Taille du fichier
11254 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
242,60 €

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