Dr De holds fifteen United States and international patents. Due to his abundant research contributions in the areas of cancer, metabolic diseases, organic and medicinal chemistry, and neuroscience, he has earned the distinction of Fellow of the Royal Society of Chemistry in 2010, and was subsequently awarded the status of Chartered Chemist in 2011. He is an elected Councilor in the American Chemical Society (San Diego section). He is editorial board member of Anticancer Agents in Medicinal Chemistry and Current Organic Synthesis.