Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals



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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2022-01-09



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Description

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Pages
156 pages
Collection
Springer Theses
Parution
2022-01-09
Marque
Springer
EAN papier
9789811681653
EAN PDF
9789811681660

Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
15
Taille du fichier
5458 Ko
Prix
158,24 €
EAN EPUB
9789811681660

Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
15
Taille du fichier
34703 Ko
Prix
158,24 €