Téléchargez le livre : Antibody Glycosylation
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Description

This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy.Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols.

Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike.

Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Pages
591 pages
Collection
Experientia Supplementum
Parution
2021-10-22
Marque
Springer
EAN papier
9783030769116
EAN PDF
9783030769123
Informations sur l'ebook
Nombre pages copiables
5
Nombre pages imprimables
59
Taille du fichier
15585 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
137,14 €
EAN EPUB
9783030769123
Informations sur l'ebook
Nombre pages copiables
5
Nombre pages imprimables
59
Taille du fichier
34284 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
137,14 €

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