Téléchargez le livre : Protein Instability at Interfaces During Drug Product Development

Protein Instability at Interfaces During Drug Product Development

Fundamental Understanding, Evaluation, and Mitigation de

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Éditeur :

Springer


Collection :

AAPS Advances in the Pharmaceutical Sciences Series

Paru le : 2021-02-12

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Description


Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity.  This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas.
 
Pages
338 pages
Collection
AAPS Advances in the Pharmaceutical Sciences Series
Parution
2021-02-12
Marque
Springer
EAN papier
9783030571764
EAN PDF
9783030571771
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
33
Taille du fichier
6359 Ko
Prix
108,89 €
EAN EPUB
9783030571771
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
33
Taille du fichier
15749 Ko
Prix
108,89 €

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