Téléchargez le livre : Protein Kinase C in Cancer Signaling and Therapy

Protein Kinase C in Cancer Signaling and Therapy



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Éditeur :

Humana


Collection :

Current Cancer Research

Paru le : 2010-06-10



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Description
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Pages
494 pages
Collection
Current Cancer Research
Parution
2010-06-10
Marque
Humana
EAN papier
9781607615422
EAN EPUB
9781607615439
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
49
Taille du fichier
1710 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
210,99 €

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