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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2014-04-11

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Description

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Pages
184 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2014-04-11
Marque
Springer
EAN papier
9783319058788
EAN EPUB
9783319058795
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
18
Taille du fichier
1925 Ko
Prix
148,39 €

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