Téléchargez le livre : Cellular Peptide Hormone Synthesis and Secretory Pathways

Cellular Peptide Hormone Synthesis and Secretory Pathways

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Éditeur :

Springer


Collection :

Results and Problems in Cell Differentiation

Paru le : 2010-03-10

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Description
The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.
Pages
239 pages
Collection
Results and Problems in Cell Differentiation
Parution
2010-03-10
Marque
Springer
EAN papier
9783642118340
EAN EPUB
9783642118364
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
23
Taille du fichier
1823 Ko
Prix
210,99 €

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