Téléchargez le livre : Cancer Genome and Tumor Microenvironment

Cancer Genome and Tumor Microenvironment



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Éditeur :

Springer


Collection :

Cancer Genetics

Paru le : 2010-01-23



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Description
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
Pages
480 pages
Collection
Cancer Genetics
Parution
2010-01-23
Marque
Springer
EAN papier
9781441907103
EAN EPUB
9781441907110
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
48
Taille du fichier
2744 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
210,99 €

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